Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
methyl paraben
CAS # 99-76-3
Alternative Name
methyl-p-hydroxybenzoate
Categories*
Food additives and contact material
Medical/Veterinary/Research
Personal care product/Cosmetic ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD. 2002. Oestrogenic activity of parabens in MCF7 human breast cancer cells. Journal of Steroid Biochemistry & Molecular Biology 80(1):49-60.
Chen JG, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284.
Gomez E, Pillon A, Fenet H, Rosain D, Duchesne MJ, Nicolas JC, Balaguer P, Casellas C. 2005. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. J Toxicol Environ Health A 68(4):239-251.
Routledge EJ, Parker J, Odum J, Ashby J, Sumpter JP. 1998. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol Appl Pharmacol 153(1):12-19.
Song BL, Li HY, Peng DR. 1989. In vitro spermicidal activity of parabens against human spermatozoa. Contraception 39(3):331-335.
*Category References
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.