Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
mono-2-(ethylhexyl)phthalate
CAS # 4376-20-9
Alternative Names
MEHP
mono(2-ethylhexyl)phthalate
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308.
Lampen A, Zimnik S, Nau H. 2003. Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells. Toxicol Appl Pharmacol 188(1):14-23.
Lloyd SC, Foster PMD. 1988. Effect of mono-(2-ethylhexyl)phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cells. Toxicol Appl Pharmacol 95(3):484-489.
Thysen B, Morris PL, Gatz M, Bloch E. 1990. The effect of mono(2-ethylhexyl) phthalate on Sertoli cell transferrin secretion in vitro. Toxicol Appl Pharmacol 106(1):154-157.
Treinen KA, Dodson WC, Heindel JJ. 1990. Inhibition of FSH-stimulated cAMP accumulation and progesterone production by mono(2-ethylhexyl) phthalate in rat granulosa cell cultures. Toxicol Appl Pharmacol 106(2):334-340.
*Category References
Itoh H, Yoshida K, Masunaga S. 2007. Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urine. Environ Sci Technol 41(13):4542-4547.