Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
monohydroxymethoxychlor
CAS # 28463-03-8
Alternative Name
2-(p-hydroxyphenyl)-2-(p-methoxyphenyl)-1,1,1-trichloroethane
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM. 2000. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol Sci 54(1):138-153.
Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. 2000. Interaction of methoxychlor and related compounds with estrogen receptor [alpha] and [beta], and androgen receptor: structure-activity studies. Mol Pharmacol 58(4):852-858.
Ousterhout J, Struck RF, Nelson JA. 1981. Estrogenic activities of methoxychlor metabolites. Biochem Pharmacol 30(20):2869-2871.
*Category References
Kupfer D, Bulger WH, Theoharides AD. 1990. Metabolism of methoxychlor by hepatic P-450 monooxygenases in rat and human. 1. Characterization of a novel catechol metabolite. Chem Res Toxicol 3(1):8-16.