Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
nicotine
CAS # 54-11-5
Categories*
Biogenic compound
Medical/Veterinary/Research
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Gyekis J, Anthony K, Foreman JE, Klein LC, Vandenbergh DJ. 2010. Perinatal nicotine exposure delays genital development in mice. Reprod Toxicol 29(3):378-30.
Izrael M, Van der Zee EA, Slotkin TA, Yanai J. 2004. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. J Neurosci Res 78(4):499-507.
Qiao D, Seidler FJ, Slotkin TA. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol Appl Pharmacol 206(1):17-26.
*Category References
Compendium of Pesticide Common Names (CPCN).
US EPA. 2008. Reregistration Eligibility Decision Document for Nicotine.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.