Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,2',5,5'-tetrachlorobiphenyl
CAS # 35693-99-3
Alternative Name
PCB-52
Category*
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Jansen HT, Cooke PS, Porcelli J, Liu T-C, Hansen LG. 1993. Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reprod Toxicol 7(3):237-248.
Pessah, I. N., L. G. Hansen, T. E. Albertson, C. E. Garner, T. A. Ta, Z. Do, K. H. Kim and P. W. Wong (2006). "Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1)." Chem Res Toxicol 19(1): 92-101.
*Category References
CDPH. 1988. Polychlorinated Biphenyls (PCBs). Fact Sheet.
UNEP. 1999. Guidlines for the Identification of PCBs and Materials Containing PCBs.
US EPA. 2012. Aroclor and other PCB mixtures.