Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
parathion
CAS # 56-38-2
Alternative Name
ethyl-parathion
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Klotz DM, Arnold SF, McLachlan JA. 1997. Inhibition of 17 beta-estradiol and progesterone activity in human breast and endometrial cancer cells by carbamate insecticides. Life Sci 60(17):1467-1475.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Mota LC, Hernandez JP, Baldwin WS. 2010. Constitutive androgen receptor-null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism. Drug Metab Dispos 38(9):1582-1588.
Rattner BA, Clarke RN, Ottinger MA. 1986. Depression of plasma luteinizinag hormone concentration in quail by the anticholinesterase insecticide parathion. Comparative Biochemistry & Physiology C 83(2):451-453.
Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.
*Category References
Compendium of Pesticide Common Names (CPCN).
US EPA. 2012. Pesticide Reregistration Status for Organophosphates.
US National Library of Medicine. Haz-Map.