Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perchloroethylene
CAS # 127-18-4
Alternative Names
tetrachloroethylene
PERC
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Medical/Veterinary/Research
Pesticide ingredient
Solvent
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Carney EW, Thorsrud BA, Dugard PH, Zablotny CL. 2006. Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene. Birth Defects Res B Dev Reprod Toxicol 77(5):405-412.
Fredriksson A, Danielsson BR, Eriksson P. 1993. Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates. Toxicol Lett 66(1):13-19.
Honma T, Sudo A, Miyagawa M, Sato M, Hasegawa H. 1980. Effects of exposure to trichloroethylene and tetrachloroethylene on the contents of acetylcholine, dopamine, norepinephrine and serotonin in rat brain. Ind Health 18(4):171-178.
Shafer TJ, Bushnell PJ, Benignus VA, Woodward JJ. 2005. Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. J Pharmacol Exp Ther 315(3):1109-1118.
*Category References
Eisele AP, Mukerjee S, Smith LA, Thoma ED, Whitaker DA, Oliver KD, Wu T, Colon M, Alston L, Cousett TA, and Miller MC, 2016. Volatile organic compounds at two oil and natural gas production well pads in Colorado and Texas using passive samplers. Journal of the Air & Waste Management Association, 66(4), pp.412-419.
Rich A, Grover JP, Sattler ML. 2014. An exploratory study of air emissions associated with shale gas development and production in the Barnett Shale. J Air Waste Manag Assoc 64(1):61-72.
US Dept of Health & Human Services. Household Products Database.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.