Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorobutanesulfonate
CAS # 375-73-5
Alternative Names
PFBS
perfluorobutanesulfonic acid
Categories*
Flame retardant
Household product ingredient
Industrial additive
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Feng X, Cao X, Zhao S, Wang X, Hua X, Chen L and Chen L. 2017. Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental abnormalities in female offspring. Toxicological Sciences, 155(2):409-419.
Gorrochategui E, Pérez-Albaladejo E, Casas J, Lacorte S and Porte C. 2014. Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells. Toxicol Appl Pharmacol 277(2):124-130.
Lou QQ, Zhang YF, Zhou Z, Shi YL, Ge YN, Ren DK, Xu HM, Zhao YX, Wei WJ and Qin ZF. 2013. Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis. Ecotoxicology 22(7):1133-1144.
Rosenmai AK, Ahrens L, Godec T, Lundqvist J and Oskarsson A. 2017. Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J Appl Toxicol 38(2):219-226.
Vongphachan V, Cassone CG, Wu D, Chiu S, Crump D, Kennedy SW. 2011. Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells. Toxicol Sci 120(2):392-402.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl 31(2):161-169.