Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluoroheptanoic acid
CAS # 375-85-9
Alternative Name
PFHpA
Categories*
Flame retardant
Food additives and contact material
Household product ingredient
Industrial additive
Metabolite/Degradate
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Rosenmai AK, Ahrens L, Godec T, Lundqvist J and Oskarsson A. 2017. Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J Appl Toxicol 38(2):219-226.
Vongphachan V, Cassone CG, Wu D, Chiu S, Crump D, Kennedy SW. 2011. Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells. Toxicol Sci 120(2):392-402.
Wolf CJ, Schmid JE, Lau C and Abbott BD. 2012. Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): further investigation of C4–C12 compounds. Reprod Toxicol 33(4):546-551.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl 31(2):161-169.
Rosenmai AK, Taxvig C, Svingen T, Trier X, Vugt‐Lussenburg BMA, Pedersen M, Lesné L, Jégou B and Vinggaard AM. 2016. Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro. Andrology 4(4):662-672.
Zafeiraki E, Costopoulou D, Vassiliadou I, Bakeas E and Leondiadis L. 2014. Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere, 94:169-176.