Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorohexanesulfonate
CAS # 355-46-4
Alternative Name
PFHxS
Categories*
Flame retardant
Household product ingredient
Industrial additive
Metabolite/Degradate
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Cassone CG, Vongphachan V, Chiu S, Williams, KL, Letcher RJ, Pelletier E, Crump D and Kennedy SW. 2012. In ovo effects of perfluorohexane sulfonate and perfluorohexanoate on pipping success, development, mRNA expression, and thyroid hormone levels in chicken embryos. Toxicological Sciences 127(1):216-224.
Kjeldsen LS and Bonefeld-Jørgensen EC. 2013. Perfluorinated compounds affect the function of sex hormone receptors. Environ Sci Pollut Res Int 20(11):8031-8044.
Long M, Ghisari M and Bonefeld-Jørgensen EC. 2013. Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 20(11):8045-8056.
Maisonet M, Calafat AM, Marcus M, Jaakkola JJ and Lashen H. 2015. Prenatal exposure to perfluoroalkyl acids and serum testosterone concentrations at 15 years of age in female ALSPAC study participants. Environ Health Perspect 123(12):1325-1330.
Rosen MB, Das KP, Rooney J, Abbott B, Lau C and Corton JC. 2017. PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology 387:95-107.
Rosenmai AK, Ahrens L, Godec T, Lundqvist J and Oskarsson A. 2017. Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J Appl Toxicol 38(2):219-226.
Shah-Kulkarni, S., Kim, B.M., Hong, Y.C., Kim, H.S., Kwon, E.J., Park, H., Kim, Y.J. and Ha, E.H., 2016. Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls. Environment international, 94, pp.607-613.
Vongphachan V, Cassone CG, Wu D, Chiu S, Crump D, Kennedy SW. 2011. Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells. Toxicol Sci 120(2):392-402.
Watkins AM, Wood CR, Lin MT and Abbott BD. 2015. The effects of perfluorinated chemicals on adipocyte differentiation in vitro. Mol Cell Endocrinol 400:90-101.
Zhao B, Lian Q, Chu Y, Hardy DO, Li XK and Ge RS. 2011. The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances. The J Steroid Biochem Mol Biol 125(1-2):143-147.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl 31(2):161-169.