Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorononanoic acid
CAS # 375-95-1
Alternative Name
PFNA
Categories*
Flame retardant
Food additives and contact material
Household product ingredient
Industrial additive
Metabolite/Degradate
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Kjeldsen LS and Bonefeld-Jørgensen EC. 2013. Perfluorinated compounds affect the function of sex hormone receptors. Environ Sci Pollut Res Int 20(11):8031-8044.
Long M, Ghisari M and Bonefeld-Jørgensen EC. 2013. Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 20(11):8045-8056.
Rosenmai AK, Ahrens L, Godec T, Lundqvist J and Oskarsson A. 2017. Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J Appl Toxicol 38(2):219-226.
Shah-Kulkarni, S., Kim, B.M., Hong, Y.C., Kim, H.S., Kwon, E.J., Park, H., Kim, Y.J. and Ha, E.H., 2016. Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls. Environment international, 94, pp.607-613.
Vongphachan V, Cassone CG, Wu D, Chiu S, Crump D, Kennedy SW. 2011. Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells. Toxicol Sci 120(2):392-402.
Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP and Wang SL. 2014. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environ Health Perspect 122(5):529-534.
Wolf CJ, Takacs ML, Schmid JE, Lau C, Abbott BD. 2008. Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths. Toxicol Sci 106(1):162-171.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl 31(2):161-169.
Rosenmai AK, Taxvig C, Svingen T, Trier X, Vugt‐Lussenburg BMA, Pedersen M, Lesné L, Jégou B and Vinggaard AM. 2016. Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro. Andrology 4(4):662-672.
Zafeiraki E, Costopoulou D, Vassiliadou I, Bakeas E and Leondiadis L. 2014. Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere, 94:169-176.