Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorooctanoic acid
CAS # 335-67-1
Alternative Name
PFOA
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Metabolite/Degradate
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Kim S, Choi K, Ji K, Seo J, Kho Y, Park J, Kim S, Park S, Hwang I, Jeon J and Yang H. 2011. Trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones. Environ Sci Technol 45(17):7465-7472.
Kjeldsen LS and Bonefeld-Jørgensen EC. 2013. Perfluorinated compounds affect the function of sex hormone receptors. Environ Sci Pollut Res Int 20(11):8031-8044.
Rosenmai AK, Ahrens L, Godec T, Lundqvist J and Oskarsson A. 2017. Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells. J Appl Toxicol 38(2):219-226.
Tsai MS, Lin CY, Lin CC, Chen MH, Hsu SH, Chien KL, Sung FC, Chen PC and Su TC. 2015. Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults. International journal of hygiene and environmental health, 218(5), pp.437-443.
Wei Y, Liu Y, Wang J, Tao Y, Dai J. 2008. Toxicogenomic analysis of the hepatic effects of perfluorooctanoic acid on rare minnows (Gobiocypris rarus). Toxicol Appl Pharmacol 226(3):285-297.
Wolf CJ, Schmid JE, Lau C and Abbott BD. 2012. Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): further investigation of C4–C12 compounds. Reprod Toxicol 33(4):546-551.
Zhao B, Lian Q, Chu Y, Hardy DO, Li XK and Ge RS. 2011. The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances. The J Steroid Biochem Mol Biol 125(1-2):143-147.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
RPS. 2009. Analysis of the risks arising from the industrial use of Perfuorooctanoic acid (PFOA) and Ammonium Perfluorooctanoate (APFO) and from their use in consumer articles. Evaluation of the risk reduction measures for potential restrictions on the manufacture, placing on the market and use of PFOA and APFO. (pp 11,30)
US National Library of Medicine. Hazardous Substances Data Bank.