Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
permethrin
CAS # 52645-53-1
Alternative Name
(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate
Categories*
Household product ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Brander SM, He G, Smalling KL, Denison MS, Cherr GN. 2012. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem 31(12):2848-2855.
Du G, Shen O, Sun H, Fei J, Lu C, Song L, Xia Y, Wang S, Wang X. 2010. Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays. Toxicol Sci 116(1):58-66.
Eil C, Nisula BC. 1990. The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. J Steroid Biochem 35(3/4):409-414.
Go V, Garey J, Wolff MS, Pogo BGT. 1999. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Environ Health Perspect 107(3):173-177.
Jin Y, Chen R, Sun L, Wang W, Zhou L, Liu W, Fu Z. 2009 Mar. Enantioselective induction of estrogen-responsive gene expression by permethrin enantiomers in embryo-larval zebrafish. Chemosphere 74(9):1238-1244.
Kim SS, Lee RD, Lim KJ, Kwack SJ, Rhee GS, Seok JH, Lee GS, An BS, Jeung EB, Park KL. 2005. Potential estrogenic and antiandrogenic effects of permethrin in rats. Journal of Reproduction and Development 51(2):201-210.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Lemaire G, Mnif W, Pascussi JM, Pillon A, Rabenoelina F, Fenet H, Gomez E, Casellas C, Nicolas JC, Cavailles V, Duchesne MJ, Balaguer P. 2006. Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. Toxicol Sci 91(2):501-509.
Nillos MG, Chajkowski S, Rimoldi JM, Gan J, Lavado R, Schlenk D. 2010. Stereoselective Biotransformation of Permethrin to Estrogenic Metabolites in Fish. Chem Res Toxicol 23(10):1568-1575.
*Category References
Compendium of Pesticide Common Names (CPCN).
US Dept of Health & Human Services. Household Products Database.
US National Library of Medicine. Haz-Map.