Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
p-hydroxybenzoic acid
CAS # 99-96-7
Alternative Name
p-hydroxybenzoate
Categories*
Biogenic compound
Byproduct/Intermediate/Reactant
Food additives and contact material
Industrial additive
Personal care product/Cosmetic ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Lemini C, Silva G, Timossi C, Luque D, Valverde A, González-Martínez M, Hernandez A, Rubio-Póo C, Chávez Lara B, Valenzuela F. 1997. Estrogenic effects of p-hydroxybenzoic acid in CD1 mice. Environ Res 75(2):130-134.
Peungvicha P, Thirawarapan SS, Watanabe H. 1998. Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root. Jpn J Pharmacol 78(3):395-398.
Pugazhendhi D, Pope GS, Darbre PD. 2005. Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines. J Appl Toxicol 25(4):301-319.
*Category References
US National Library of Medicine. Hazardous Substances Data Bank.