Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
propanil
CAS # 709-98-8
Alternative Names
DCPA (Japan)
3,4-dichloropropionanilide. [See also DCPA (USA)]
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Salazar KD, Miller MR, Barnett JB, Schafer R. 2006. Evidence for a novel endocrine disruptor: The pesticide propanil requires the ovaries and steroid synthesis to enhance humoral immunity. Toxicol Sci 93(1):62-74.
Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H. 2008. In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere 74(1):155-165.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.