Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
simazine
CAS # 122-34-9
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Didier R, Lutz-Ostertag Y. 1972. Action of simazine on the genital tract of embryos from chicken and quail in vivo. C R Seances Soc Biol Fil 166(12):1691-1693.
Fan WQ, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K-I, Hayes TB, Takayanagi R, Nawata H. 2007. Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115(5):720-727.
Sanderson JT, Letcher RJ, Heneweer M, Giesy JP, van den Berg M. 2001. Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect 109(10):1027-1031.
Tran DQ, Kow KY, McLachlan JA, Arnold SF. 1996. The inhibition of estrogen receptor-mediated responses by chloro-s-triazine-derived compounds is dependent on estradiol concentration in yeast. Biochemical & Biophysical Research Communications 227(1):140-146.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.