Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
thiram
CAS # 137-26-8
Alternative Names
thiuram
TMTD
Categories*
Antimicrobial
Household product ingredient
Industrial additive
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Han MS, Shin KJ, Kim YH, Kim SH, Lee T, Kim E, Ryu SH, Suh PG. 2003. Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells. Neurotoxicology 24(3):425-434.
Serio R, Long RA, Taylor JE, Tolman RL, Weppelman RM, Olson G. 1984. The antifertility and antiadrenergic actions of thiocarbamate fungicides in laying hens. Toxicol Appl Pharmacol 72(2):333-342.
Stoker TE, Cooper RL, Goldman JM, Andrews JE. 1996. Characterization of pregnancy outcome following thiram-induced ovulatory delay in the female rat. Neurotoxicol Teratol 18(3):277-282.
Stoker TE, Goldman JM, Cooper RL. 1993. The dithiocarbamate fungicide thiram disrupts the hormonal control of ovulation in the female rat. Reprod Toxicol 7:211-218.
Stoker TE, Jeffay SC, Zucker RM, Cooper RL, Perreault SD. 2003. Abnormal fertilization is responsible for reduced fecundity following thiram-induced ovulatory delay in the rat. Biol Reprod 68(6):2142-2149.
*Category References
Compendium of Pesticide Common Names (CPCN).
US Dept of Health & Human Services. Household Products Database.
US National Library of Medicine. Hazardous Substances Data Bank.