Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
toluene
CAS # 108-88-3
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Pesticide ingredient
Plastic/Rubber
Solvent
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Brown-Woodman PD, Webster WS, Picker K, Huq F. 1994. In vitro assessment of individual and interactive effects of aromatic hydrocarbons on embryonic development of the rat. Reprod Toxicol 8(2):121-135.
Kassotis CD, Klemp KC, Vu DC, Lin CH, Meng CX, Besch-Williford CL, Pinatti L, Zoeller RT, Drobnis EZ, Balise VD, et al. 2015 in press. Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice. Endocrinology:en20151375.
Ono A, Sekita K, Ogawa Y, Hirose A, Suzuki S, Saito M, Naito K, Kaneko T, Furuya T, Kawashima K, Yasuhara K, Matsumoto K, Tanaka S, Inoue T, Kurokawa Y. 1996. Reproductive and developmental toxicity studies of toluene. II. Effects of inhalation exposure on fertility in rats. Journal of Environmental Pathology, Toxicology & Oncology 15(1):9-20.
*Category References
National Pesticide Information Retrieval System.
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.
Waxman HA, Markey EJ, and DeGette D. 2011. Chemicals used in hydraulic fracturing. United States House of Representatives Committee on Energy and Commerce Minority Staff.