Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
tributyltin
CAS # 20763-88-6
Alternative Name
TBT (ionic)
Categories*
Food additives and contact material
Household product ingredient
Industrial additive
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Atanasov AG, Nashev LG, Tan S, Baker ME, Odermatt A. 2005. Organotins disrupt the 11[beta]-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect 113(11):1600-1606.
Bettin C, Oehlmann J, Stroben E. 1996. TBT-induced imposex in marine neogastropods is mediated by an increasing androgen level. Helgoland Marine Research [Helgolander Meeresuntersuchungen] 50(3):299-317.
Gibbs PE, Pascoe PL, Burt GR. 1988. Sex change in the female dog-whelk, Nucella lapillus, induced by tributyltin from antifouling paints. Journal of the Marine Biological Association of the United Kingdom 68(4):715-731.
*Category References
Abraha AB, Whalen MM. 2009. The role of p44/42 activation in tributyltin-induced inhibition of human natural killer cells: effects of MEK inhibitors. J Appl Toxicol 29(2):165-173.
Atanasov AG, Nashev LG, Tan S, Baker ME, Odermatt A. 2005. Organotins disrupt the 11[beta]-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect 113(11):1600-1606.
US FDA. 2011. List of Indirect Additives Used in Food Contact Substances.
Yamada S, Fuji Y, Mikami E, Kawamura N, Hayakawa J. 1993. Small-scale survey of organotin compounds in household commodities. J AOAC Int 76(2):436-441.