Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
tributyltin bromide
CAS # 1461-23-0
Alternative Name
TBT bromide
Categories*
Household product ingredient
Industrial additive
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Nakanishi T, Hiromori Y, Yokoyama H, Koyanagi M, Itoh N, Nishikawa J, Tanaka K. 2006. Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta. Biochem Pharmacol 71(9):1349-1357.
*Category References
Abraha AB, Whalen MM. 2009. The role of p44/42 activation in tributyltin-induced inhibition of human natural killer cells: effects of MEK inhibitors. J Appl Toxicol 29(2):165-173.
Atanasov AG, Nashev LG, Tan S, Baker ME, Odermatt A. 2005. Organotins disrupt the 11[beta]-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect 113(11):1600-1606.
Yamada S, Fuji Y, Mikami E, Kawamura N, Hayakawa J. 1993. Small-scale survey of organotin compounds in household commodities. J AOAC Int 76(2):436-441.