Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
tributyltin chloride
CAS # 1461-22-9
Alternative Names
TBT chloride
tributylchlorostannane
Categories*
Byproduct/Intermediate/Reactant
Medical/Veterinary/Research
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Duft M, Schulte-Oehlmann U, Tillmann M, Markert B, Oehlmann J. 2003. Toxicity of triphenyltin and tributyltin to the freshwater mudsnail Potamopyrgus antipodarum in a new sediment biotest. EnvironToxicol Chem 22(1):145-152.
Ema M, Kurosaka R, Amano H, Ogawa Y. 1995. Further evaluation of the developmental toxicity of tributyltin chloride in rats. Toxicology 96(3):195-201.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Snoeij NJ, Penninks AH, Seinen W. 1988. Dibutyltin and tributyltin compounds induce thymus atrophy in rats due to a selective action on thymic lymphoblasts. Int J Immunopharmacol 10(7):891-899.
*Category References
eChemPortal. ESIS.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.