Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
triclocarban
CAS # 101-20-2
Alternative Names
TCC
3,4,4'-trichlorocarbanilide
N-(chloro)-N'-(3,4-dichloro)-phenylurea (CDCPU)
Categories*
Antimicrobial
Household product ingredient
Personal care product/Cosmetic ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: Receptor-based bioassay screens. Environ Health Perspect 116(9):1203-1210.
Chen J, Ahn KC, Gee NA, Mohamed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. 2007. Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology 149(3):1173-1179.
Chung E, Genco MC, Megrelis L, Ruderman JV. 2011. Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos. Proc Natl Acad Sci U S A 108(43):17732-17737.
*Category References
US Dept of Health & Human Services. Household Products Database.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.