Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
triphenyltin chloride
CAS # 639-58-7
Alternative Names
TPT chloride
fentin chloride
chlorotriphenyltin
triphenylchlorotin
chlorotriphenylstannane
Categories*
Industrial additive
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Duft M, Schulte-Oehlmann U, Tillmann M, Markert B, Oehlmann J. 2003. Toxicity of triphenyltin and tributyltin to the freshwater mudsnail Potamopyrgus antipodarum in a new sediment biotest. EnvironToxicol Chem 22(1):145-152.
Ema M, Miyawaki E, Harazono A, Ogawa Y. 1997. Effects of triphenyltin chloride on implantation and pregnancy in rats. Reprod Toxicol 11(2-3):201-206.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Schulte-Oehlmann U, Tillmann M, Markert B, Oehlmann J, Watermann B, Scherf S. 2000. Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part II: triphenyltin as a xeno-androgen. Ecotoxicology 9(6):399-412.
Snow RL, Hays RL. 1983. Phasic distribution of seminiferous tubules in rats treated with triphenyltin compounds. Bull Environ Contam Toxicol 31(6):658-665.
Yanik, S.C., Baker, A.H., Mann, K.K. and Schlezinger, J.J., 2011. Organotins are potent activators of PPARĪ³ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells. Toxicological Sciences, 122(2), pp.476-488.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.