Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

vinclozolin metabolite M1

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CAS # 119209-27-7

Alternative Name

2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid

Category*
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Laws SC, Carey SA, Kelce WR, Cooper RL, Gray LE. 1996. Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro. Toxicology 112(3):173-182.

Wong CI, Kelce WR, Sar M, Wilson EM. 1995. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem 270(34):19998-20003.

*Category References

Wong CI, Kelce WR, Sar M, Wilson EM. 1995. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem 270(34):19998-20003.

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