Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

2,3,4,4',5-pentachlorobiphenyl

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CAS # 74472-37-0

Alternative Name

PCB-114

Category*
Industrial additive

Evidence Supporting This Chemical as an Endocrine Disruptor

Bandiera S, Sawyer TW, Campbell MA, Fujita T, Safe S. 1983. Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis. Biochem Pharmacol 32(24):3803-3813.

Krishnan V, Safe S. 1993. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol Appl Pharmacol 120(1):55-61.

*Category References

CDPH. 1988. Polychlorinated Biphenyls (PCBs). Fact Sheet.

UNEP. 1999. Guidlines for the Identification of PCBs and Materials Containing PCBs.

US EPA. 2012. Aroclor and other PCB mixtures.

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