Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
xylene (mixed isomers)
CAS # 1330-20-7
Alternative Names
xylenes
dimethylbenzene
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Pesticide ingredient
Plastic/Rubber
Solvent
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Brown-Woodman PD, Webster WS, Picker K, Huq F. 1994. In vitro assessment of individual and interactive effects of aromatic hydrocarbons on embryonic development of the rat. Reprod Toxicol 8(2):121-135.
Hass U, Lund SP, Simonsen L, Fries AS. 1995. Effects of prenatal exposure to xylene on postnatal development and behavior in rats. Neurotoxicol Teratol 17(3):341-349.
Kassotis CD, Klemp KC, Vu DC, Lin CH, Meng CX, Besch-Williford CL, Pinatti L, Zoeller RT, Drobnis EZ, Balise VD, et al. 2015 in press. Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice. Endocrinology:en20151375.
*Category References
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.
Ziemkiewicz PF, Quaranta JD, Darnell A, Wise R. 2014. Exposure pathways related to shale gas development and procedures for reducing environmental and public risk. J Nat Gas Sci Eng 16(0):77-84.
Ziemkiewicz PF, Thomas He Y. 2015. Evolution of water chemistry during Marcellus Shale gas development: A case study in West Virginia. Chemosphere 134:224-231.