Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

ziram

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CAS # 137-30-4

Alternative Names

zinc dimethyldithiocarbamate

zinc bis(dimethyldithiocarbamate)

Categories*
Household product ingredient
Industrial additive
Pesticide ingredient
Plastic/Rubber

Evidence Supporting This Chemical as an Endocrine Disruptor

Cilievici O, Craciun C, Ghidus E. 1983. Decreased fertility, increased dominant lethals, skeletal malformations induced in the mouse by ziram fungicide. Rev. Roum. Morphology Embryology & Physiology 29(3):159-165.

Han MS, Shin KJ, Kim YH, Kim SH, Lee T, Kim E, Ryu SH, Suh PG. 2003. Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells. Neurotoxicology 24(3):425-434.

Marinovich M, Guizzetti M, Ghilardi F, Viviani B, Corsini E, Galli CL. 1997. Thyroid peroxidase as toxicity target for dithiocarbamates. Arch Toxicol 71(8):508-512.

Ohnishi T, Yoshida T, Igarashi A, Muroi M, Tanamoto KI. 2008. Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. FEMS Immunology & Medical Microbiology 52(2):293-295.

Serio R, Long RA, Taylor JE, Tolman RL, Weppelman RM, Olson G. 1984. The antifertility and antiadrenergic actions of thiocarbamate fungicides in laying hens. Toxicol Appl Pharmacol 72(2):333-342.

Thangavel P, Ramaswamy M, Sumathiral K, Amutha K. 2005. Individual and combined effects of dimecron-ziram on the levels of serum prolactin and selected minerals of an edible freshwater fish, Oreochromis mossambicus (Peters). Pestic Biochem Physiol 81(1):24-31.

*Category References

Compendium of Pesticide Common Names (CPCN).

US Dept of Health & Human Services. Household Products Database.

US National Library of Medicine. Haz-Map.

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