Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
hexabromocyclododecane
CAS # 3194-55-6 (1,2,5,6,9,10-hexabromocyclododecane) / 25637-99-4 (hexabromocyclododecane)
Alternative Names
HBCD
1,2,5,6,9,10-hexabromocyclododecane
Categories*
Flame retardant
Household product ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Hamers T, Kamstra JH, Sonneveld E, Murk AJ, Kester MH, Andersson PL, Legler J, Brouwer A. 2006. In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicol Sci 92(1):157-173.
Yamada-Okabe T, Sakai H, Kashima Y, Yamada-Okabe H. 2005. Modulation at a cellular level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4'-diiodobiphenyl (DIB), and nitrofen (NIP). Toxicol Lett 155(1):127-133.
*Category References
US National Library of Medicine. Hazardous Substances Data Bank.