Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

4-hydroxy-2,2',3,4',5,5'-hexachlorobiphenyl

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CAS # 145413-90-7

Alternative Name

4-OH-PCB-146

Category*
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.

Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol 142(1):160-168.

Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol 142(1):160-168.

*Category References

ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).

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