Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4'-hydroxy-2,2',3,4,6-pentachlorobiphenyl
CAS # 150304-10-2
Alternative Names
4-'OH-PCB-88
4-hydroxy-2,2',3',4',6'-pentachlorobiphenyl
2,2',3',4',6'-pentachloro-4-biphenylol
3-chloro-4-(2,3,4,6-tetrachlorophenyl)phenol
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. Toxicol Appl Pharmacol 145(1):111-123.
Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).