Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
isopropyl paraben
CAS # 4191-73-5
Alternative Name
isopropyl p-hydroxybenzoate
Category*
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Okubo T, Yokoyama Y, Kano K, Kano I. 2001. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ER[alpha] and PR. Food Chem Toxicol 39(12):1225-1232.
Terasaki M, Kamata R, Shiraishi F, Makino M. 2009. Evaluation of estrogenic activity of parabens and their chlorinated derivatives by using the yeast two-hybrid assay and the enzyme-linked immunosorbent assay. Environ Toxicol Chem 28(1):204-208.
Vo TT, Jeung EB. 2009. An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. Toxicol Sci 112(1):68-77.
*Category References
EWG.