Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
perfluorobutyric acid
CAS # 375-22-4
Alternative Names
PFBA
perfluorobutyrate
perfluorobutanoic acid
Categories*
Food additives and contact material
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Foreman JE, Chang SC, Ehresman DJ, Butenhoff JL, Anderson CR, Palkar PS, Kang BH, Gonzalez FJ, Peters JM. 2009. Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. Toxicol Sci 110(1):204-211.
Li Y, Cheng Y, Xie Z and Zeng F. 2017. Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones. Scientific Reports 7:43380.
*Category References
Houtz EF, Higgins CP, Field JA and Sedlak DL. 2013. Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. Environ Sci Technol 47(15):8187-8195.
Rosenmai AK, Taxvig C, Svingen T, Trier X, Vugt‐Lussenburg BMA, Pedersen M, Lesné L, Jégou B and Vinggaard AM. 2016. Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro. Andrology 4(4):662-672.
US National Library of Medicine. Haz-Map.
Zafeiraki E, Costopoulou D, Vassiliadou I, Bakeas E and Leondiadis L. 2014. Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere, 94:169-176.