Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene

print
pdf

CAS # 13464-24-9

Alternative Names

MBP

4,4'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisphenol

Category*
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Ishibashi H, Watanabe N, Matsumura N, Hirano M, Nagao Y, Shiratsuchi H, Kohra S, Yoshihara S, Arizono K. 2005. Toxicity to early life stages and an estrogenic effect of a bisphenol A metabolite, 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene on the medaka (Oryzias latipes). Life Sci 77(21):2643-2655.

Nagae M, Shiroyama K, Inoue M, Hara A, Takao Y, Kohra S, Ishibashi Y, Tominaga N, Yoshihara S, Arizono K. 2005. Estrogenic potency of a bisphenol A metabolite on vitellogenin synthesis in medaka, Oryzias latipes. Journal of Health Science 51(1):93-95.

Okuda K, Takiguchi M, Yoshihara S. 2010. In vivo estrogenic potential of 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat. Toxicol Lett 197(1):7-11.

Yamaguchi A, Ishibashi H, Kohra S, Arizono K, Tominaga N. 2005. Short-term effects of endocrine-disrupting chemicals on the expression of estrogen-responsive genes in male medaka (Oryzias latipes). Aquat Toxicol 72(3):239-249.

Yoshihara S, Mizutare T, Makishima M, Suzuki N, Fujimoto N, Igarashi K, Ohta S. 2004. Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency. Toxicol Sci 78(1):50-59.

*Category References

Yoshihara S, Mizutare T, Makishima M, Suzuki N, Fujimoto N, Igarashi K, Ohta S. 2004. Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency. Toxicol Sci 78(1):50-59.

CLOSE WINDOW