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The Endocrine Disruption Exchange
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The Science of Fracking and Health

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Kassotis, et al. (2018) Unconventional oil and gas chemicals and wastewater-impacted water samples promote adipogenesis via PPARγ-dependent and independent mechanisms in 3T3-L1 cells.

Boulé, et al. (2018) Developmental exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters the immune system of mice.

Sapouckey, et al. (2018) Prenatal exposure to unconventional oil and gas operation chemical mixtures altered mammary gland development in adult female mice. 

Kassotis, et al. (2018) Endocrine-disrupting activities and organic contaminants associated with oil and gas operations in Wyoming groundwater.

Kassotis, et al. (2016) Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site.

Kassotis, et al. (2016) Adverse reproductive and developmental health outcomes following prenatal exposure to a hydraulic fracturing chemical mixture in female c57b1/6 mice. 

Kassotis, et al. (2015) Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice.

Kassotis, et al. (2015) Endocrine-disrupting chemicals in oil and natural gas operations: potential environmental contamination and recommendations to assess complex environmental mixtures.

Metabolic disrupting potential of unconventional oil and gas operation chemicals and mixtures

Research has shown hormone disruption in mice exposed during pregnancy to a mixture of common fracking chemicals at likely environmentally relevant concentrations. Dr. Chris Kassotis presents his new research demonstrating metabolic disrupting activity in the fracking chemical mixture, fracking wastewater, and in surface water near unconventional oil and gas operations. The study found all mixtures were capable of inducing fat cell development and proliferation at very low concentrations and identifies the likely underlying molecular mechanisms for some of these effects.

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Photo of Dr. KassotisChris Kassotis, PhD is an NRSA Postdoctoral Research Fellow in the Nicholas School of the Environment at Duke University. He completed his PhD at the University of Missouri working with Susan Nagel to assess unconventional oil and gas operations as a novel source of endocrine disrupting chemicals in water, and the potential for adverse human and animal health outcomes from exposure. He is now working in Heather Stapleton's lab at Duke to assess the adipogenic activity of complex chemical mixtures present in indoor house dust and other matrices as well as to develop new assays to isolate and characterize novel endocrine disruptors in complex mixtures.