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Male Reproductive System — WEEK 10

At approximately day 1

First androgen-dependent lateral buds of prostate appear from urogenital sinus mesenchyme.

Reference

vom Saal FS, Montano MM, Wang MH. 1992. Sexual differentiation in mammals. In: Colborn T, Clement C, eds. Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human ConnectionVolume XXI. Princeton, NJ: Princeton Scientific Publishing Co., Inc. p 17-83. (Mehlman MA, ed. Advances in Modern Environmental Toxicology; 21).

At approximately day 1

Male and female urogenital sinuses become distinguishable.

Duration: 2 weeks

Reference [PubMed Link]

Marker PC, Donjacour AA, Dahiya R, Cunha GR. 2003. Hormonal, cellular, and molecular control of prostatic development. Dev Biol 253(2):165-174.

At approximately day 1

First epithelial outgrowths (prostatic buds) arise and begin to grow rapidly in length, branch and canalize.

Reference [PubMed Link]

Cunha GR, Donjacour AA, Cooke PS, Mee S, Bigsby RM, Higgins SJ, Sugimura Y. 1987. The endocrinology and developmental biology of the prostate. Endocr Rev 8:338-362.