First androgen-dependent lateral buds of prostate appear from urogenital sinus mesenchyme.
vom Saal FS, Montano MM, Wang MH. 1992. Sexual differentiation in mammals. In: Colborn T, Clement C, eds. Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human ConnectionVolume XXI. Princeton, NJ: Princeton Scientific Publishing Co., Inc. p 17-83. (Mehlman MA, ed. Advances in Modern Environmental Toxicology; 21).
Male and female urogenital sinuses become distinguishable.
Duration: 2 weeks
Marker PC, Donjacour AA, Dahiya R, Cunha GR. 2003. Hormonal, cellular, and molecular control of prostatic development. Dev Biol 253(2):165-174.
First epithelial outgrowths (prostatic buds) arise and begin to grow rapidly in length, branch and canalize.
Cunha GR, Donjacour AA, Cooke PS, Mee S, Bigsby RM, Higgins SJ, Sugimura Y. 1987. The endocrinology and developmental biology of the prostate. Endocr Rev 8:338-362.