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4 results for: Bisphenol A, Central Nervous System — WEEK 6

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Decreased mating behaviors; decreased sociosexual exploration; decreased social interest

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 400 μg/kg bw/d

Route of administration: dissolved in arachis oil and fed with a pipette

Exposure duration: gestational day 14 – post-natal day 6 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 27)

Age of measurement: 35, 45 and 55 days of age

 Reference [PubMed Link]
Dessi-Fulgheri F, Porrini S, Farabollini F. 2002. Effects of perinatal exposure to bisphenol A on play behavior of female and male juvenile rats. Environ Health Perspect 110 (suppl 3):403-407.
Study Results Study Details References

Results for Bisphenol A

Decreased anxiety and decreased exploration in males; decreased motor activity and exploration in females

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 400 μg/kg bw/d

Route of administration: dissolved in arachis oil and fed through a micropipette

Exposure duration: gestational day 14 – post-natal day 6 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 27)

Age of measurement: 85 days of age

 Reference [PubMed Link]
Farabollini F, Porrini S, Dessi-Fulgherit F. 1999. Perinatal exposure to the estrogenic pollutant bisphenol A affects behavior in male and female rats. Pharmacology, Biochemistry & Behavior 64(4):687-694.
Study Results Study Details References

Results for Bisphenol A

Decreased time spent nursing pups; increased time spent nest building, resting alone and self-grooming

Subjects: CD-1 mice

Chemical: Bisphenol A

Low doses tested: 10 μg/kg bw/d

Route of administration: dissolved in corn oil and fed with a pipette

Exposure duration: gestational day 14 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 11)

Age of measurement: in adulthood during lactation

 Reference [PubMed Link]
Palanza PL, Howdeshell KL, Parmigiani S, vom Saal FS. 2002. Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice. Environ Health Perspect 110 (suppl 3):415-422.
Study Results Study Details References

Results for Bisphenol A

Decreased time spent nursing and in the nest and increased time spent resting alone, grooming, out of the nest or nest building among mice exposed during gestation only; increased time spent resting alone was the only significant behavior among mice exposed during gestation and again in pregnant adulthood

Subjects: CD-1 mice

Chemical: Bisphenol A

Low doses tested: 10 μg/kg bw/dy

Route of administration: dissolved in corn oil and delivered through a micropipette

Exposure duration: gestational day 14 – gestational day 18, with a subset also dosed at 2.5 months of age while pregnant (comparable to human prenatal development from approximately day 1 of week 6 to day 1 of week 11)

Age of measurement: birth through adulthood

 Reference [PubMed Link]
Palanza P, Gioiosa L, vom Saal FS, Parmigiani S. 2008 Oct. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 108(2):150-7.