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1 result for: Bisphenol A, Female Reproductive System — WEEK 20

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Decreased uterine PR, ERα and Hoxa10 mRNA levels and decreased ERα protein levels on 5th day of pregnancy.

Subjects: Wistar rats

Chemical: Bisphenol A

Low doses tested: 0.5 mg/kg bw/d

Other doses tested: 20.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered subcutaneously

Exposure duration: post-natal day 1 – post-natal day 7 (comparable to human prenatal development from approximately day 1 of week 20 to day 1 of week 28)

Age of measurement: post-natal weeks 12-16

 Reference [PubMed Link]
Varayoud J, Ramos JG, Bosquiazzo VL, Lower M, Munoz-de-Toro M, Luque EH. 2011. Neonatal exposure to bisphenol A alters rat uterine implantation-associated gene expression and reduces the number of implantation sites. Endocrinology 152(3):1101-1111.