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2 results for: Bisphenol A, Female Reproductive System — WEEK 4

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Decreased body weight at some time points; increased anogenital distance at lower dose; earlier vaginal opening, earlier first estrus and decreased body weight at time of vaginal opening, all at higher dose only

Subjects: ICR/Jcl mice

Chemical: Bisphenol A

Low doses tested: 2 or 20 μg/kg bw/d

Route of administration: dissolved in sesame oil and injected subcutanously

Exposure duration: gestational day 11 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 9)

Age of measurement: from birth to adulthood

 Reference [PubMed Link]
Honma S, Suzuki A, Buchanan DL, Katsu Y, Watanabe H, Iguchi T. 2002. Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. Reprod Toxicol 16(2):117-122.
Study Results Study Details References

Results for Bisphenol A

Reduced time between vaginal opening and first estrus, particularly among those with highest endogenous levels of estradiol (as measured by intrauterine position)

Subjects: CF-1 mice

Chemical: Bisphenol A

Low doses tested: 2.4 μg/kg bw/d

Route of administration: dissolved in corn oil and fed orally

Exposure duration: gestational day 11 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 9)

Age of measurement: from birth to puberty

 Reference
Howdeshell KL, vom Saal FS. 2000. Developmental exposure to bisphenol A: Interaction with endogenous estradiol during pregnancy in mice. Am Zool 40(3):429-437.