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9 results for: Bisphenol A, Other Systems — WEEK 2

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Decreased body weight at 3 weeks but not at birth

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 mg/kg bw/d

Other doses tested: 50 mg/kg bw/d

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 6 – gestational day 21 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 16)

Age of measurement: birth through adulthood

 Reference
Talsness C, Fialkowski O, Gericke C, Merker H-J, Chahoud I. 2000. The effects of low and high doses of bisphenol A on the reproductive system of female and male rat offspring. Congenital Anomalies 40:S94-S107.
Study Results Study Details References

Results for Bisphenol A

Increased body weight from birth to adulthood

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 0.1 mg/kg bw/d

Other doses tested: 1.2 mg/kg bw/d (10 mg/L)

Route of administration: 1 mg/L supplied in drinking water; intake estimated

Exposure duration: gestational day 6 – post-natal day 20 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: from birth through 110 days of age

 Reference [PubMed Link]
Rubin BS, Murray MK, Damassa DA, King JC, Soto AM. 2001. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 109(7):675-680.
Study Results Study Details References

Results for Bisphenol A

Increased body weight at birth; increased body weight at 21 days and 14 weeks among females; increased body weight among males at 14 weeks on high fat diet only

Subjects: Sprague-Dawley rats

Chemical: Bisphenol A

Low doses tested: 70.0 μg/kg bw (estimated)

Route of administration: delivered in drinking water

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: birth through adulthood

 Reference [PubMed Link]
Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS. 2009. Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect 117(10):1549-1555.
Study Results Study Details References

Results for Bisphenol A

Increased expression of genes involved in lipogenesis

Subjects: Sprague-Dawley rats

Chemical: Bisphenol A

Low doses tested: 70.0 μg/kg bw (estimated)

Route of administration: delivered in drinking water

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: birth through adulthood

 Reference [PubMed Link]
Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS. 2009. Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect 117(10):1549-1555.
Study Results Study Details References

Results for Bisphenol A

Increased lung inflammation in females in the aerosol challenge when exposed to OVA and OVA+LPS in females exposed to 50.0 μg/kg and 50.0 or 500.0 μg/kg respectively. Decreased airway eosinophil numbers with OVA aerosol challenge at 0.5, 5.0, or 50.0 μg/kg in females.

Subjects: C57BL/6 mice

Chemical: Bisphenol A

Low doses tested: 0.5, 5.0, 50.0 or 500.0 μg/kg bw/d

Route of administration: dissolved in peanut oil and admininstered by gavage

Exposure duration: gestational day 6 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal weeks 6-10

 Reference [PubMed Link]
Bauer SM, Roy A, Emo J, Chapman TJ, Georas SN, Lawrence BP. 2012. The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood. Toxicol Sci 130(1):82-93.
Study Results Study Details References

Results for Bisphenol A

Increased body weight at post-natal week 13 in F1 females exposed to 0.5 mg/kg. Increased body weight at post-natal weeks 3 and 11 in F2 males. In F2 females, increased body weight at post-natal weeks 3, 4, and 13 at 0.05 mg/kg exposure and at weeks 3 and 13 at 0.5 mg/kg exposure.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 0.05, 0.5 mg/kg bw/d

Other doses tested: 5 mg/kg bw/d

Route of administration: delivered in feed daily

Exposure duration: gestational day 6 – post-natal week 13-15 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal days 1, 3, 7, 10 and post-natal weeks 13 and 15

 Reference [PubMed Link]
Kobayashi K, Ohtani K, Kubota H, Miyagawa M. 2010. Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL/6J mice. Congenit Anom (Kyoto) 50(3):159-170.
Study Results Study Details References

Results for Bisphenol A

Increased absolute heart weight at post-natal week 13 in F2 males exposed to 0.05 mg/kg.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 0.05, 0.5 mg/kg bw/d

Other doses tested: 5 mg/kg bw/d

Route of administration: delivered in feed daily

Exposure duration: gestational day 6 – post-natal week 13-15 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal days 1, 3, 7, 10 and post-natal weeks 13 and 15

 Reference [PubMed Link]
Kobayashi K, Ohtani K, Kubota H, Miyagawa M. 2010. Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL/6J mice. Congenit Anom (Kyoto) 50(3):159-170.
Study Results Study Details References

Results for Bisphenol A

Increased absolute liver weight at post-natal week 13 in F1 females exposed to 0.05 mg/kg.

Subjects: C57BL/6J mice

Chemical: Bisphenol A

Low doses tested: 0.05, 0.5 mg/kg bw/d

Other doses tested: 5 mg/kg bw/d

Route of administration: delivered in feed daily

Exposure duration: gestational day 6 – post-natal week 13-15 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal days 1, 3, 7, 10 and post-natal weeks 13 and 15

 Reference [PubMed Link]
Kobayashi K, Ohtani K, Kubota H, Miyagawa M. 2010. Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL/6J mice. Congenit Anom (Kyoto) 50(3):159-170.
Study Results Study Details References

Results for Bisphenol A

Decreased body weight in males on post-natal day 21 at 0.05 mg/kg dose level and on post-natal day 56 at the 0.05 and 0.5 mg/kg dose levels.

Subjects: ICR mice

Chemical: Bisphenol A

Low doses tested: 0.05, 0.5 mg/kg bw/d

Other doses tested: 5.0 and 50.0 mg/kg bw/d

Route of administration: dissolved in sesame oil and delivered orally

Exposure duration: gestational day 7 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal days 21 and 56

 Reference [PubMed Link]
Xu XH, Zhang J, Wang YM, Ye YP, Luo QQ. 2010. Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-D-aspartate receptors of hippocampus in male offspring mice. Horm Behav 58(2):326-333.