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3 results for: Bisphenol A, Limbic System — WEEK 2

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Bisphenol A

Up-regulated expression of RC3/Neurogranin in the dentate gyrus of the hippocampus

Subjects: SD rats

Chemical: Bisphenol A

Low doses tested: 1 mg/kg bw/d

Other doses tested: 10 and 50 mg/kg bw/d

Route of administration: fed on a wafer

Exposure duration: gestational day 6 – post-natal day 15 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 36)

Age of measurement: 15 days of age

 Reference [PubMed Link]
Zoeller RT, Bansal R, Parris C. 2005. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 146(2):607-612.
Study Results Study Details References

Results for Bisphenol A

Reduced hippocampal phospho-ERK in F2 mice of F0 exposed to 1.0 mg/kg

Subjects: C57BL/6 mice

Chemical: Bisphenol A

Low doses tested: 0.1 or 1.0 mg/kg bw/d

Other doses tested: 10.0 mg/kg bw/d

Route of administration: dissolved in corn oil and delivered intraperitoneally

Exposure duration: gestational day 6 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 2 to day 1 of week 9)

Age of measurement: post-natal day 42, 44, 56, 63 and 65 (F2 generation)

 Reference [PubMed Link]
Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. 2012. High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Toxicology 296(1-3):73-82.
Study Results Study Details References

Results for Bisphenol A

On post-natal day 21 hippocampal NR1 protein levels were decreased in males exposed to 0.05 and 0.5 mg/kg and NR2B protein levels were decreased in males exposed to 0.5 mg/kg. Decreased hippocampal NR1, NR2A, and NR2B protein levels in males exposed to both 0.05 and 0.5 mg/kg. In addition, ERβ protein levels were decreased in males exposed to 0.5 mg/kg

Subjects: ICR mice

Chemical: Bisphenol A

Low doses tested: 0.05, 0.5 mg/kg bw/d

Other doses tested: 5.0 and 50.0 mg/kg bw/d

Route of administration: dissolved in sesame oil and delivered orally

Exposure duration: gestational day 7 – post-natal day 21 (comparable to human prenatal development from approximately day 1 of week 2 to beyond birth)

Age of measurement: post-natal days 21 and 56

 Reference [PubMed Link]
Xu XH, Zhang J, Wang YM, Ye YP, Luo QQ. 2010. Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-D-aspartate receptors of hippocampus in male offspring mice. Horm Behav 58(2):326-333.