The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased age at vaginal opening at low and high doses; increased estrus length at low and middle doses; decreased uterine weight at highest dose |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.025, 0.060, 0.3 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent) Route of administration: injected subcutaneously Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Faqi AS, Dalsenter PR, Merker HJ, Chahoud I. 1998. Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicology & Applied Pharmacology 150(2):383-392. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased Ahr in immunochemical staining of uterine tissue in F1, F2 and F3 generations. Increased uterine Cyp1a2 expression in the F1 generation. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 2.0 ng/L Route of administration: dissolved in DMSO and delivered in drinking water Exposure duration: gestational day 0 – daily in drinking water (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: post-natal day 1, 4, 21, and 35 |
Reference [PubMed Link] Huang L, Huang R, Ran XR, Liu HY, Zhang Y, Dai LJ, Li B. 2011. Three-generation experiment showed female C57BL/6J mice drink drainage canal water containing low level of TCDD-like activity causing high pup mortality. J Toxicol Sci 36(6):713-724. |