The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased percentage with vaginal opening at 42 through 50 days |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 40 percent) Route of administration: injected subcutaneously Exposure duration: gestational day 19 – adulthood (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased number of proliferating cells and BRDU labelled nuclei in ureteric epithelial cells at 6.5 days culture at 10 nM; increased number of proliferating cells at 6.5 days culture at 1.0 nM |
Subjects: C57BL/6N mice Chemical: Dioxin (TCDD) Low doses tested: 0.1, 1.0, or 10.0 nM Route of administration: in vitro culture Exposure duration: gestational day 18 – in vitro culture (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 23) Age of measurement: 4 through 14 days culture |
Reference [PubMed Link] Bryant PL, Reid LM, Schmidt JE, Buckalew AR, Abbott BD. 2001. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on fetal mouse urinary tract epithelium in vitro. Toxicology 162(1):23-34. |