The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased sperm number from cauda epididymis and daily sperm production in puberty and adulthood; increased sperm transit rate in puberty and adulthood; increased percent of abnormal sperm in adulthood |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.025, 0.060, 0.3 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 20 percent) Route of administration: injected subcutaneously Exposure duration: pre-conception – post-natal day 22 (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Faqi AS, Chahoud I. 1998. Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation. Bulletin of Environmental Contamination & Toxicology 61(4):462-469. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased ventral prostate weight at 28 and 120 days of age; |
Subjects: Holtzman rats Chemical: Dioxin (TCDD) Low doses tested: 0.4 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses of 0.08 μg/kg during mating, pregnancy, and lactational periods Route of administration: delivered orally via gavage Exposure duration: preconception – weaning (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Ikeda M, Tamura M, Yamashita J, Suzuki C, Tomita T. 2005. Repeated in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure affects male gonads in offspring, leading to sex ratio changes in F-2 progeny. Toxicology & Applied Pharmacology 206(3):351-355. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased time to balano-preputial separation (BPS) at 42 to 70 days of age |
Subjects: Wistar(Han) rats Chemical: Dioxin (TCDD) Low doses tested: 0.0028, 0.0093 or 0.053 μg/kg/day Route of administration: delivered in daily diet Exposure duration: 12 weeks prior to mating – birth (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through 120 days of age |
Reference [PubMed Link] Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-233. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased proportion of abnormal sperm, mean total homogenization resistant spermatid count, and ratio of testes weight to body weight on day 70 at 0.053 μg/kg/day |
Subjects: Wistar(Han) rats Chemical: Dioxin (TCDD) Low doses tested: 0.0028, 0.0093 or 0.053 μg/kg/day Route of administration: delivered in daily diet Exposure duration: 12 weeks prior to mating – birth (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth) Age of measurement: birth through 120 days of age |
Reference [PubMed Link] Bell DR, Clode S, Fan MQ, Fernandes A, Foster PMD, Jiang T, Loizou G, Macnicoll A, Miller BG, Rose M, Tran L, White S. 2007. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99(1):224-233. |