The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative and absolute anogenital distance on post-natal day 30 |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered by i.p. injection Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8) Age of measurement: post-natal days 30 and 60 |
Reference [PubMed Link] Weber Lozada K, Keri RA. 2011. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 85(3):490-497. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative testes and epididymal weight on post-natal day 60. Decreased testicular AR expression on post-natal day 30 and increased AR expression on post-natal day 60. Decreased PCNA positive testicular cells on both post-natal days 30 and 60. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered by i.p. injection Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8) Age of measurement: post-natal days 30 and 60 |
Reference [PubMed Link] Weber Lozada K, Keri RA. 2011. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod 85(3):490-497. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased ventral UGM Cyp1b1 expression with decreased ERK activation in UGE cells. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 5.0 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: gestational day 15.5 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8) Age of measurement: gestational day 16.5 |
Reference [PubMed Link] Vezina CM, Hardin HA, Moore RW, Allgeier SH, Peterson RE. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits fibroblast growth factor 10-induced prostatic bud formation in mouse urogenital sinus. Toxicol Sci 113(1):198-206. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative and absolute anogenital distance on post-natal day 30 |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered by i.p. injection Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8) Age of measurement: post-natal days 30 and 60 |
Reference [PubMed Link] Jin MH, Ko HK, Hong CH, Han SW. 2008. In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse. Yonsei Med J 49(5):843-850. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative testes and epididymal weight on post-natal day 60. Decreased testicular AR expression on post-natal day 30 and increased AR expression on post-natal day 60. Decreased PCNA positive testicular cells on both post-natal days 30 and 60. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered by i.p. injection Exposure duration: gestational day 15 – single dose (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 8) Age of measurement: post-natal days 30 and 60 |
Reference [PubMed Link] Jin MH, Ko HK, Hong CH, Han SW. 2008. In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse. Yonsei Med J 49(5):843-850. |