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2 results for: Dioxin, Immune System — WEEK 1

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased relative weight of thymus in F3 generation at 0.01 μg/kg/day

Subjects: Sprague-Dawley rats

Chemical: Dioxin (TCDD)

Low doses tested: 0.001 or 0.01 μg/kg bw/day

Other doses tested: 0.1 μg/kg bw/day

Route of administration: delivered daily in feed

Exposure duration: 90 days prior to mating – fed daily (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: 90 days prior to mating through 396 days of age

 Reference [PubMed Link]
Murray FJ, Smith FA, Nitschke KD, Humiston CG, Kociba RJ, Schwetz BA. 1979 Sep 15. Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol Appl Pharmacol 50(2):241-52.
Study Results Study Details References

Results for Dioxin (TCDD)

Decreased number of immunodominant viral peptide NP366-372/Db + CD8+ T-cells nine days after infection with 120 HAU of influenza A virus in mediastinal lymph nodes (MLN) for gestational plus lactational, and lactational only TCDD exposure; decreased number of cytotoxic T lymphocyte effector cells (CTLe) defined phenotypically as CD44hi CD621lo CD8+ and expansion of NP366-372/Db + CD8+ T-cells in MLN in recipients that had been lethally irradiated and received bone marrow cells from offspring of TCDD treated dams

Subjects: C57BL/6 mice

Chemical: Dioxin (TCDD)

Low doses tested: 1.0 μg/kg bw on gestational days 0, 7, and 14 and at 2 days of age

Route of administration: dissolved in peanut oil and delivered through gavage

Exposure duration: gestational day 0 (cross-fostered at 2 days of age) – last dose at 2 days of age (comparable to human prenatal development from approximately day 1 of week 1 to beyond birth)

Age of measurement: eight through 10 weeks of age

 Reference [PubMed Link]
Hogaboam JP, Moore AJ, Lawrence BP. 2008 Mar. The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system. Toxicol Sci 102(1):160-70.