The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Varying effects on thymocytes at different stages of development. |
Subjects: C57BL/6 mice Chemical: Dioxin (TCDD) Low doses tested: 0.5, 1.0, or 10.0 nM Route of administration: in vitro culture Exposure duration: post-natal day 15 – 7 days in vitro culture (comparable to human prenatal development from approximately day 1 of week 32 to beyond birth) Age of measurement: 7 days culture |
Reference [PubMed Link] Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. 1998. 2,3,7,8-tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicology & Applied Pharmacology 149(2):167-177. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Varying effects on thymocyte differentiation, proliferation and apoptosis. |
Subjects: bcl-2 transgenic mice Chemical: Dioxin (TCDD) Low doses tested: 10.0 nM Route of administration: in vitro culture Exposure duration: post-natal day 15 – 7 days in vitro culture (comparable to human prenatal development from approximately day 1 of week 32 to beyond birth) Age of measurement: 7 days culture |
Reference [PubMed Link] Lai ZW, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. 2000. Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicology & Applied Pharmacology 168(1):15-24. |