The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased body weight at 7 days of age at both doses and additionally at 14, 21 and 31 days of age at the higher dose |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw Other doses tested: Initial dose was followed by weekly maintenance doses (at 40 percent) Route of administration: injected subcutaneously Exposure duration: gestational day 19 – adulthood (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: birth through adulthood |
Reference [PubMed Link] Thiel R, Koch E, Ulbrich B, Chahoud I. 1994. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin - effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69(2):79-86. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased body weight at 3.0 μg/kg |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 3.0 μg/kg bw Route of administration: injected subcutaneously Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 77 days of age |
Reference Korte M, Stahlmann R, Thiel R, Nagao T, Chahoud I, Vanloveren H, Vos JG, Neubert D. 1991. Resistance to trichinella-spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23(11-12):1845-1854. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased relative liver weight |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 3.0 μg/kg bw Route of administration: injected subcutaneously Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 77 days of age |
Reference Korte M, Stahlmann R, Thiel R, Nagao T, Chahoud I, Vanloveren H, Vos JG, Neubert D. 1991. Resistance to trichinella-spiralis infection, induction of hepatic monooxygenases, and concentrations in thymus and liver in rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere 23(11-12):1845-1854. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased EROD activity in liver homogenate in post-natally exposed conditions only |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.003, 0.03, or 0.3 μg/kg bw Route of administration: injected subcutaneously Exposure duration: gestational day 19 and cross-fostered at birth – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 2 through 21 days of age |
Reference Korte M, Stahlmann R, Neubert D. 1990. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD tissue concentrations after single treatment during pregnancy. Chemosphere 20(7-9):1193-1198. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased body weight of males and females |
Subjects: Line C (highly sensitive to TCDD) rats Chemical: Dioxin (TCDD) Low doses tested: 1.0 μg/kg bw Route of administration: dissolved in corn oil and delivered orally Exposure duration: gestational day 19 – single dose (comparable to human prenatal development from approximately day 1 of week 10 to day 1 of week 11) Age of measurement: 40 days of age |
Reference [PubMed Link] Miettinen HM, Alaluusua S, Tuomisto J, Viluksela M. 2002. Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: The role of exposure time. Toxicol Appl Pharmacol 184(1):57-66. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Increased relative body weight at 42 through 84 days of age at loading and maintenance doses of 0.3 and 0.12 μg/kg respectively |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 μg/kg bw Other doses tested: loading dose of 1.0 μg/kg and maintenance doses of 0.12 or 0.4 μg/kg Route of administration: dissolved in corn oil and injected subcutaneously Exposure duration: gestational day 19 – 12 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: 42 through 84 days of age |
Reference [PubMed Link] Neubert R, Stahlmann R, Korte M, Vanloveren H, Vos JG, Golor G, Webb JR, Helge H, Neubert D. 1993. Effects of small doses of dioxins on the immune-system of marmosets and rats. Ann N Y Acad Sci 685:662-686. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased body weight at 14, 21, and 31 days of age at 1.0 μg/kg |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses Route of administration: injected subcutaneously Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: 7 through 31 days of age |
Reference Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231. |
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased (delayed) fur development at 7 days of age |
Subjects: Wistar rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw initial dose, with 0.4 or 0.12 μg/kg weekly maintenance doses Route of administration: injected subcutaneously Exposure duration: gestational day 19 – at 5 weeks of age (comparable to human prenatal development from approximately day 1 of week 10 to beyond birth) Age of measurement: 7 through 31 days of age |
Reference Thiel R, Korte M, Chahoud I, Neubert D. 1992. Locomotor-activity and postnatal-development of rats after exposure to 2,3,7,8-TCDD during the late fetal and early postnatal-period. Chemosphere 25(7-10):1227-1231. |