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1 result for: Chlorpyrifos, Endocrine System — WEEK 8

The weeks shown in color represent the start and end points of chemical exposure for each study.
Study Results Study Details References

Results for Chlorpyrifos

Increased thyroid hormone levels (tT3, tT4, T3U and FTI) in females

Subjects: Swiss Webster mice

Chemical: Chlorpyrifos

Low doses tested: 1.0 or 5.0 mg/kg bw/d

Route of administration: dissolved in DMSO and injected subcutaneously

Exposure duration: gestational day 17 – gestational day 20 (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 16)

Age of measurement: birth through adulthood

 Reference [PubMed Link]
Haviland JA, Butz DE, Porter WP. 2010. Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero. Reprod Toxicol 29(1):74-79.