The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for Bisphenol AIncreased MAP2- and synapsin I- positive areas, and synaptic density, at 100 nM but decreased them at 1000 nM
Subjects: SD rat hippocampal cells
Chemical: Bisphenol A
Low doses tested: 1, 10, 100 or 1000 nM
Route of administration: dissolved and added to culture media
Exposure duration: gestational day 15 plus 3 days in culture – gestational day 15 plus 10 days in culture (comparable to human prenatal development from approximately day 1 of week 8 to day 1 of week 22)
Age of measurement: 15 days post-fertilization plus 10 days in vitro
|Reference [PubMed Link]
Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y, Watanabe C. 2008. Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias. Toxicology in Vitro 22(1):1-9.